Arteriosclerosis and the promise of GPIIb/IIIa inhibitors in stroke.

Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report.

OBJECTIVE To unravel crucial von Willebrand factor (VWF) interactions that are detrimental in stroke development. METHODS AND RESULTS VWF(-/-) mice received gene transfer to express mutants of VWF defective either in binding to fibrillar collagen, glycoprotein (GP)Ibα or GPIIb/IIIa, and underwent 60 minutes of transient middle cerebral artery occlusion. In VWF(-/-) mice reconstituted with VWF...

Rescue treatment of thromboembolic complications during endovascular treatment of cerebral aneurysms.

BACKGROUND AND PURPOSE Acute intraprocedural thrombus formation complicating endovascular cerebral aneurysm treatment is often treated with intra-arterial or intravenous administration of thrombolytic agents or glycoprotein IIb/IIIa (GpIIb/IIIa) inhibitors. We sought to evaluate the morbidity and mortality associated with such treatments using a large multihospital database. METHODS Using the...

Thoughts evoked by MATCH and other trials.

Are Two “Antiplatelet” Drugs Better Than One? Many different processes are involved in platelet activation. Most drugs affect one of these chemical reactions. Theoretically, platelet functions (secretion, aggregation, and adhesion) can be reduced most effectively by using 1 agent or by inhibiting the final step in the attachment of the platelet to fibrin at the level of the glycoprotein IIb/III...

Density of Platelet GPIIb-IIIa and Bleeding Severity in Iranian Patients with Glanzmann’s Thrombasthenia

Platelet glycoprotein IIb/IIIa inhibitors: basic and clinical aspects.

Glycoprotein IIb/IIIa (GPIIb-IIIa) complexes (integrin aIIbb3) mediate platelet aggregation by binding fibrinogen or von Willebrand factor (vWF), protein cofactors that form bridges between adjacent platelets. The cross-linked adhesive proteins assemble platelets into the aggregate. Agents that block the function of the GPIIb-IIIa complex of platelets constitute a powerful new generation of ant...